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Unsourced material may be challenged and removed. LOCs can handle extremely small fluid volumes down to less than pico liters. However, strictly regarded “lab-on-a-chip” indicates generally the scaling of single or multiple lab processes down to chip-format, whereas “µTAS” is dedicated to the integration of the total sequence of lab processes to perform chemical analysis. The term “lab-on-a-chip” was introduced when it turned out that µTAS technologies were applicable for more than only analysis purposes. Next to pressure sensors, airbag sensors and other mechanically movable structures, fluid handling devices were developed. The first LOC analysis system was a gas chromatograph, developed in 1979 by S.